Welcome to the Shaye Lab
at the University of Illinois at Chicago
We study the cell biology and genetic regulation underlying biological tube formation
Lab News and Blog
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The C.elegans excretory canal (ExCa) is a single-cell tube that provides an excellent model to study biological tube formation (tubulogenesis). Genes that regulate ExCa development have human homologs implicated in kidney and vascular disease. We use the ExCa to discover and study new tubulogenesis regulators.
Some genes that regulate ExCa tubulogenesis have been implicated in angiogenesis; the creation of new blood vessels from existing ones. We use human cell culture models to ask whether genes that we discover in C. elegans play roles in angiogenesis.